Prostaglandins

900123 11-beta PGF2α

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900108 15-beta PGF2α

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900122 15-keto PGF2α

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900111 15beta-PGF1α

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900118 (15R)-PGE2

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900142 PGA2

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900120 PGB1

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900143 PGB2

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900113 PGE1-d9

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900117 PGE2

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900114 PGE2-EA

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900105 PGF1α

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900112 PGF1α-d9

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900110 PGF1ß

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900121 PGF2α

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900119 PGF2β

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900100 Prostaglandin E1 (PGE1)

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Prostaglandins are bioactive signaling molecules synthesized from arachidonate by the action of cyclooxygenase (COX) isoenzymes and subsequently by PG synthase. Following formation by COX, PGH₂ may be converted by PG synthase into numerous products including: PGI₂, PGE₂, PGD₂, PGF_2α, and thromboxane A₂. Importantly, the letter designates the composition of the prostane or oxane ring; whereas the subscript number indicates the quantity of double bonds. Biologically, prostaglandins are well-known to be key mediators of the inflammatory response, and their role in the resolution of inflammation is an active area of investigation. As with other eicosanoid species, the combined efforts of lipidomic and cellular biology techniques will provide a basis for the continued identification and understanding of the role of prostaglandins in mediating health and disease and improving therapeutic design. With unparalleled purity, Avanti’s unlabeled and deuterated prostaglandins will certainly be our next claim to flame!

References:

Buczynski MW, Dumlao DS, Dennis EA. Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology [published correction appears in J Lipid Res. 2009 Jul;50(7):1505]. J Lipid Res. 2009;50(6):1015.

Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol. 2011;31(5):986.

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