Saturated & Unsaturated Fatty Acid PI, PIP & LPI

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850176 06:0 PI(3,4,5)P3

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850174 06:0 PI(3,5)P2

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850183 08:0 PI(3,4)P2

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850186 08:0 PI(3,4,5)P3

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850184 08:0 PI(3,5)P2

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850182 08:0 PI(4)P

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850185 08:0 PI(4,5)P2

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850181 08:0 PI

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850187 08:0 PI(3)P

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330720 15:0-18:1 PI

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850142 16:0-18:1 PI

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850157 16:0-18:1 PI(4)P

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850141 16:0 PI

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850188 18:0-20:4 PI(3,4)P2

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850166 18:0-20:4 PI(3,4,5)P3

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850164 18:0-20:4 PI(3,5)P2

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850165 18:0-20:4 PI(4,5)P2

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850158 18:0-20:4 PI(4)P

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850144 18:0-20:4 PI

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850189 18:0-20:4 PI(3)P

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850190 18:0-20:4 PI(5)P

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850143 18:0 PI

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850156 18:1 PI(3,4,5)P3

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850155 18:1 PI(4,5)P2

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850149 18:1 PI

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850153 18:1 PI(3,4)P2

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850154 18:1 PI(3,5)P2

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850150 18:1 PI(3)P

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850151 18:1 PI(4)P

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850152 18:1 PI(5)P

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PI, PIP & LPI

Phosphoinositides (PI) are minority components of cellular membranes in eukaryotes. PI’s are similar to other phospholipids, but the head group is the cyclic myo-inositol. This inositol head group has free hydroxyl groups at positions D2-D6 and the hydroxyl groups at D3, D4, and D5 are readily phosphorylated by lipid kinases. The seven combinatorially phosphorylated forms of the inositol head group result in informational content. These PI molecules act as acidic addresses identifying different membranes and providing instructions to proteins about how to behave with those membranes. These various phosphorylated inositol groups are found in the endoplasmic reticulum, early and late endosomes, trans-Golgi, secretory granules, and the plasma membrane.

Lysophosphatidylinositol (LPI) is believed to play an important role in several diseases. LPI can affect several cell functions such as cell growth, differentiation, and mobility in cell types such as cancer cells, endothelial cells, and nerve cells. G-protein coupled receptor 55 (GPR55) has been proposed as a potential LPI receptor. Evidence shows that LPI plays a key role in metabolic functions and possibly metabolic diseases.

Falkenburger BH, Jensen JB, Dickson EJ, Suh BC, Hille B. Phosphoinositides: lipid regulators of membrane proteins. J Physiol. 2010;588(Pt 17):3179-3185. doi:10.1113/jphysiol.2010.192153

Arifin SA, Falasca M. Lysophosphatidylinositol Signalling and Metabolic Diseases. Metabolites. 2016;6(1):6. Published 2016 Jan 15. doi:10.3390/metabo6010006

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Saturated & Unsaturated Fatty Acid PI, PIP & LPI

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