Chenodeoxycholic acid disulfate (trisodium salt) A80319 (Previously 700319) 3α, 7α -dihydroxy-5β-cholan-24-oic acid disulfate trisodium salt

Chenodeoxycholic Acid Disulfate is a human metabolite and a derivative of one of the primary bile acids (BAs) - chenodeoxycholic acid.

In the human body, the metabolite is synthesized in the process of sulfation - a conjugation of sulfate group with a hydroxy group in the liver and the intestinal tract.

Chenodeoxycholic acid (CDCA / chenocholic acid), is a well-known of ursodeoxycholic acid and a primary BA. It’s also formed in the liver from cholesterol catabolism through a series of enzymatic reactions. CDCA owns a variety of properties, most important one of which is the prevention of gallstone formation through several mechanisms. It inhibits cholesterol production in the liver and its absorption in the intestines and directly dissolves cholesterol. So, chenocholic acid is a compound with many applications in pharmacology and medicine. It has positive effects on conditions such as constipation, xanthomatosis, bowel function, etc.

However, as a BA, it might show some not mild toxic abilities, when present in high concentrations.

The process of sulfation, which results in obtaining Chenodeoxycholic Acid Disulfate and is usually a minor pathway, actually neutralizes toxic BAs when they are accumulated.

Sulfated metabolites such as Chenodeoxycholic Acid Disulfate are thus a protective mechanism against the pathological consequences of BAs, and damage to different cells and tissues, especially in the liver and bile ducts.

Chenocholic acid derivative, Chenodeoxycholic Acid 7-Sulfate is a suitable compound to include in various studies in research on BAs, including CDCA itself.

Avanti’s Chenodeoxycholic Acid 7-Sulfate owns all characteristics of a high-standard detergent for successful experimental work.