14:0-6:0(C2 NBD) PI(4,5)P2, TEA salt 880188 1-tetradecanoyl-2-{6[2-(7-nitro-2-1,3-benzoxadiazol-4-yl)acetyl](aminohexanoyl)}-sn-glycero-3-phosphoinositol-4,5-diphosphate (triethylamine salt)

Phosphoinositides (PI) are minority components of cellular membranes in eukaryotes. PI’s are similar to other phospholipids, but the head group is the cyclic myo-inositol. This inositol head group has free hydroxyl groups at positions D2-D6 and the hydroxyl groups at D3, D4, and D5 are readily phosphorylated by lipid kinases. The seven combinatorially phosphorylated forms of the inositol head group result in informational content. These PI molecules act as acidic addresses identifying different membranes and providing instructions to proteins about how to behave with those membranes. These various phosphorylated inositol groups are found in the endoplasmic reticulum, early and late endosomes, trans-Golgi, secretory granules, and the plasma membrane. This Lipid is tagged with Nitrobenzoxadiazole (NBD). NBD was discovered several decades ago but continues to be a popular choice for fluorescent labeling of lipids due to its desirable fluorescence characteristics. Due to the ease at which NBD can be attached to biomolecules, it makes NBD compounds valuable assets in lipid membrane studies, lysosomal lipid body analysis, and for drug screening.