Deuterated Bile Acids

700369 3α,12α-dihydroxy-5β-cholestanoic acid-d5

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700368 3α,7α-dihydroxy-5β-cholestanoic acid-d5

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700370 3α,7α,12α-trihydroxy-5β-cholestanoic acid-d5

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330839 3β,5α,6β-trihydroxycholanoic acid-d4

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330259 Chenodeoxycholic acid-(2,2,4,4-d4)

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330840 cholenic acid-d4

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330256 Cholic acid-d4

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330257 Deoxycholic acid-d4

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330277 Glycocholic acid-d4

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330273 Glycochenodeoxycholic acid-d4

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330271 Glycodeoxycholic acid-d4

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330275 Glycolithocholic acid-d4

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330276 Glycoursodeoxycholic acid-d4

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330258 Lithocholic acid-d4

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330274 Taurochenodeoxycholic acid-d4, sodium salt

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330278 Taurocholic acid-d4, sodium salt

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330272 Taurodeoxycholic acid-d4, sodium salt

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330280 Taurolithocholic acid-d4, sodium salt

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330279 Tauroursodeoxycholic acid-d4, sodium salt

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330260 Ursodeoxycholic acid-d4

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Bile acids are potent digestive surfactants which promote the absorption of lipids. They also represent the primary pathway for cholesterol catabolism and account for approximately 50% of the daily turnover of cholesterol [2]. However, bile acids are no longer limited to solely that. Bile acids have now been recognized as hormones involved in the regulation of various metabolic processes. Bile acids regulate not only their own synthesis and enterohepatic circulation, but also triglyceride, cholesterol, glucose and energy homeostasis. Current metabolomic and lipidomic efforts aim to provide new insights into the mechanism of bile acid signaling in the regulation of lipid metabolism and the maintenance of lipid homeostasis. [1,2]

Avanti offers a comprehensive line of unlabeled and deuterated pure bile acids as a complement to primary, secondary, and/or conjugated bile acid research. Order our bile acids for use in any clinical, toxicological, or research laboratory.

[1] Qi Y, Jiang C, Cheng J, Krausz KW, Li T, Ferrell JM, Gonzalez FJ, Chiang JY. Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim Biophys Acta. 2015 Jan;1851(1):19-29. doi: 10.1016/j.bbalip.2014.04.008. Epub 2014 May 4. PMID: 24796972; PMCID: PMC4219936.

[2] Staels B, Fonseca VA. Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration. Diabetes Care. 2009 Nov;32 Suppl 2(Suppl 2):S237-45. doi: 10.2337/dc09-S355. PMID: 19875558; PMCID: PMC2811459.

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