Deuterated Bile Acids

A80369 3α,12α-dihydroxy-5β-cholestanoic acid-d5

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A80368 3α,7α-dihydroxy-5β-cholestanoic acid-d5

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A80370 3α,7α,12α-trihydroxy-5β-cholestanoic acid-d5

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A83839 3β,5α,6β-trihydroxycholanoic acid-d4

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A83259 Chenodeoxycholic acid-(2,2,4,4-d4)

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A83840 cholenic acid-d4

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A83256 Cholic acid-d4

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A83257 Deoxycholic acid-d4

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A83277 Glycocholic acid-d4

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A83273 Glycochenodeoxycholic acid-d4

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A83271 Glycodeoxycholic acid-d4

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A83275 Glycolithocholic acid-d4

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A83276 Glycoursodeoxycholic acid-d4

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A83258 Lithocholic acid-d4

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A83274 Taurochenodeoxycholic acid-d4, sodium salt

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A83278 Taurocholic acid-d4, sodium salt

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A83272 Taurodeoxycholic acid-d4, sodium salt

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A83280 Taurolithocholic acid-d4, sodium salt

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A83279 Tauroursodeoxycholic acid-d4, sodium salt

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A83260 Ursodeoxycholic acid-d4

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Bile acids are potent digestive surfactants which promote the absorption of lipids. They also represent the primary pathway for cholesterol catabolism and account for approximately 50% of the daily turnover of cholesterol [2]. However, bile acids are no longer limited to solely that. Bile acids have now been recognized as hormones involved in the regulation of various metabolic processes. Bile acids regulate not only their own synthesis and enterohepatic circulation, but also triglyceride, cholesterol, glucose and energy homeostasis. Current metabolomic and lipidomic efforts aim to provide new insights into the mechanism of bile acid signaling in the regulation of lipid metabolism and the maintenance of lipid homeostasis. [1,2]

Avanti offers a comprehensive line of unlabeled and deuterated pure bile acids as a complement to primary, secondary, and/or conjugated bile acid research. Order our bile acids for use in any clinical, toxicological, or research laboratory.

[1] Qi Y, Jiang C, Cheng J, Krausz KW, Li T, Ferrell JM, Gonzalez FJ, Chiang JY. Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim Biophys Acta. 2015 Jan;1851(1):19-29. doi: 10.1016/j.bbalip.2014.04.008. Epub 2014 May 4. PMID: 24796972; PMCID: PMC4219936.

[2] Staels B, Fonseca VA. Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration. Diabetes Care. 2009 Nov;32 Suppl 2(Suppl 2):S237-45. doi: 10.2337/dc09-S355. PMID: 19875558; PMCID: PMC2811459.

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