Fixed Cationic Lipids
890700 12:0 EPC (Cl Salt)
View890701 14:0 EPC (Cl Salt)
View890860 14:0 TAP
View890717 14:1 EPC (Tf Salt)
View890705 16:0-18:1 EPC (Cl Salt)
View860775 16:0 CB (DPCB)
View890702 16:0 EPC (Cl Salt)
View860776 16:0 SB (DPSB)
View890870 16:0 TAP
View890810 18:0 DDAB
View890703 18:0 EPC (Cl Salt)
View890880 18:0 TAP
View890704 18:1 EPC (Cl Salt)
View890890 18:1 TAP (DOTAP)
View890895 18:1 TAP (DOTAP, MS Salt)
View890718 APL-718
View890719 APL-719
View890200 DC-6-14
View850310 DOBAQ
View850549 DORI
View890898 DOTMA
View810890 Fluorescent DOTAP
View790326 Fluorescent Transfection Reagent
View790310 Transfection Reagent I
ViewNucleic acid delivery is a focus area for therapeutic research across the globe. Nucleic acid cargo such as DNA, mRNA, siRNA, and CRISPR/Cas-9 gene editing technologies are negatively charged (anionic) and thus, to sequester and deliver the cargo, the delivery system needs a positively charged (cationic) component. Unlike ionizable lipids, fixed cationic lipids are constantly charged in biological environments regardless of the pH.
Fixed cationic lipids have been proven to be good transfection agents in liposomes and lipid nanoparticles. Generally considered non-toxic at lower concentrations, these lipids do present some toxicity concerns when used in higher concentrations due to the tetra substituted ammonium moiety. Avanti offers a wide range of proven fixed cationic lipids such as DOTMA or DOTAP, but new, innovative cationic lipids are constantly being added. Check out our fixed cationic lipid offerings and fuel your lipid-based nucleic acid delivery research today!