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Fixed Cationic Lipids

890700 12:0 EPC (Cl Salt)

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890701 14:0 EPC (Cl Salt)

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890860 14:0 TAP

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890717 14:1 EPC (Tf Salt)

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890705 16:0-18:1 EPC (Cl Salt)

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860775 16:0 CB (DPCB)

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890702 16:0 EPC (Cl Salt)

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860776 16:0 SB (DPSB)

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890870 16:0 TAP

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890810 18:0 DDAB

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890703 18:0 EPC (Cl Salt)

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890880 18:0 TAP

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890704 18:1 EPC (Cl Salt)

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890890 18:1 TAP (DOTAP)

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890895 18:1 TAP (DOTAP, MS Salt)

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890718 APL-718

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890719 APL-719

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890200 DC-6-14

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850310 DOBAQ

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850549 DORI

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890898 DOTMA

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810890 Fluorescent DOTAP

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790326 Fluorescent Transfection Reagent

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790310 Transfection Reagent I

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Nucleic acid delivery is a focus area for therapeutic research across the globe. Nucleic acid cargo such as DNA, mRNA, siRNA, and CRISPR/Cas-9 gene editing technologies are negatively charged (anionic) and thus, to sequester and deliver the cargo, the delivery system needs a positively charged (cationic) component. Unlike ionizable lipids, fixed cationic lipids are constantly charged in biological environments regardless of the pH.

Fixed cationic lipids have been proven to be good transfection agents in liposomes and lipid nanoparticles. Generally considered non-toxic at lower concentrations, these lipids do present some toxicity concerns when used in higher concentrations due to the tetra substituted ammonium moiety. Avanti offers a wide range of proven fixed cationic lipids such as DOTMA or DOTAP, but new, innovative cationic lipids are constantly being added. Check out our fixed cationic lipid offerings and fuel your lipid-based nucleic acid delivery research today!