Acyl Carnitine - Deuterated

A87857 24:0(d4) L-carnitine

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A87327 C10:0 L-carnitine-d9 (HCl salt)

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A87326 C12:0 L-carnitine-d9 (HCl salt)

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A87325 C14:0 L-carnitine-d9

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A87323 C16:0 L-carnitine-d9

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A87324 C18:0 L-carnitine-d9 (HCl salt)

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A87321 C18:1 L-carnitine-d9

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A87322 C18:2 L-carnitine-d9

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A87333 C2:0 L-carnitine-d9

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A87856 C26 D,L-Carnitine-d9

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A87332 C3:0 L-carnitine-d9 (HCl Salt)

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A87331 C4:0 L-carnitine-d9

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A87330 C5:0 L-carnitine-d9

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A87329 C6:0 L-carnitine-d9

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A87328 C8:0 L-carnitine-d9

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A87311 L-carnitine-d9

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Acylcarnitines are acyl esters of the quaternary ammonium compound carnitine. These esters are essential for the catabolism of fatty acids and maintenance of energy homeostasis in the human body. Acylcarnitines transport acyl groups from fatty acids into the mitochondria to generate energy. These molecules are capable of moving through the mitochondrial and cell membranes via a carnitine shuttle. There are several disorders that have been linked to acylcarnitine metabolic defects including various acyl-CoA dehydrogenase deficiencies. These defects typically manifest as encephalopathy, cardiomyopathy, and myopathy. Milder acylcarnitine abnormalities have been detected in diseases such as insulin resistance, cardiovascular disease, and Alzheimer's disease. Avanti offers deuterated acylcarnitine derivatives for use as standards when studying these molecules and their biological roles.

https://www.lipidmaps.org/resources/lipidweb/lipidweb_html/lipids/simple/carnitin/index.htm

Gerald Liew, Benita Tse, I-Van Ho, Nichole Joachim, Andrew White, Russell Pickford, David Maltby, Bamini Gopinath, Paul Mitchell, Ben Crossett; Acylcarnitine Abnormalities Implicate Mitochondrial Dysfunction in Patients With Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2020;61(8):32. doi: https://doi.org/10.1167/iovs.61.8.32.

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