DSPE-PEG2000 Maleic amide A89932 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleic acid monoamide(polyethylene glycol)-2000] (ammonium salt)

DSPE-PEG2000-Maleic Amide is a lipid excipient designed for the preparation of lipid nanoparticles (LNPs) and liposomes for drug and RNA delivery. It is derived from 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) which serves as a robust phospholipid anchor within the membrane bilayer. Chemically distinct from the ring-closed maleimide, this derivative serves as a critical non-reactive control and stability reference for formulation development. It allows researchers to validate bioconjugation efficiency by distinguishing between specific ligand coupling and non-specific binding, or to monitor the hydrolytic stability of maleimide-functionalized LNPs. This unique capability is essential for the rigorous characterization of LNPs tailored for targeted delivery.