22:6 BMP-D5 792469 bis(monodocosahexaenoylglycero)phosphate-D5 (ammonium salt)
22:6 BMP-d5 22:6 BMP (R,R) is a stereochemically defined BMP containing two 22:6 DHA chains. BMP is a low-abundance but important phospholipid enriched in late endosomal membranes, mostly associated with membrane remodeling and lipid trafficking. BMP levels and/or species profiles are often altered in lysosomal storage disorders and are commonly monitored as biomarkers of drug-induced phospholipidosis1; emerging studies also support BMP’s utility in translational biomarker panels2. With the polyunsaturated 22:6 acyl chains and defined (R,R) stereochemistry, this lipid is a valuable reference standard for lipidomics method development and LC-MS/MS quantitation, as well as for probing acyl-chain and stereochemistry-dependent BMP biology. This product is deuterated which enables the study of structure, dynamics, and function of cell membranes.
1) Meikle PJ, Duplock S, Blacklock D, Whitfield PD, Macintosh G, Hopwood JJ, Fuller M. Effect of lysosomal storage on bis(monoacylglycero)phosphate. Biochem J. 2008 Apr 1;411(1):71-8. doi: 10.1042/BJ20071043. PMID: 18052935.
2) Ørum K, Stormoen DR, Lauritsen J, Rohde M, Jäättelä M, Pappot H. An example of drug repurposing: ebastine in combination with docetaxel as a treatment for metastatic castration-resistant prostate cancer-the EXUROC prostate study, a clinical trial protocol. BMC Urol. 2025 Jul 4;25(1):154. doi: 10.1186/s12894-025-01837-0. PMID: 40611014; PMCID: PMC12226910.
