diSialo (a(2-3)-a(2-6)LacCer, Na salt A89867 diSialo (a(2-3)-a(2-6)LacCer, Na salt
The regiochemistry of sialic acid linkages is a fundamental regulator of cellular recognition, immune evasion, and pathogen entry. While typical disialogangliosides like GD3 feature tandem α(2-8) linked sialic acid chains, this specific "mixed-linkage" isomer presents a distinct binding topology. This makes it a valuable molecular tool for dissecting complex carbohydrate-protein interactions where dual-specificity or branched recognition is required. In virology, this lipid is particularly useful for investigating the binding dynamics of influenza A hemagglutinins and other viral attachment proteins, which typically must discriminate between avian-type α(2-3) and human-type α(2-6) receptors.
