GDGT A80588 Glycerol dialkyl glycerol tetraether

Distributed under license from NovoArc

GDGT (glycerol dialkyl glycerol tetraether) is an archaeal-derived tetraether lipid designed for advanced liposome and lipid nanoparticle formulation work. While other conventional phospholipids rely on ester linkages, GDGT features ether-linked hydrocarbon chains that span the membrane and form highly ordered structures that are remarkably environmentally resilient.

Thanks to their molecular makeup that alters lipid behavior under stress, GDGT-containing membranes demonstrate strong resistance to heat, oxidation, and extreme pH conditions, making the lipid particularly valuable for formulations exposed to challenging storage conditions, harsh biological environments, or extended processing workflows.

More and more, GDGT is being explored as a functional lipid component in systems where long-term integrity and membrane durability matter, thanks to its stability profile. The material is supplied through the Avanti Research™ x NovoArc collaboration, ensuring rigorous quality standards are met and supporting both exploratory research and larger-scale formulation programs.

Bulk quantity and GMP manufacturing inquiries for translational and commercial development efforts are available upon request.

Application

GDGT has been evaluated across a range of oral and injectable delivery systems incorporating small molecules, proteins, and nucleic acid therapeutics. Published formulation studies have reported substantial improvements in gastrointestinal stability and oral uptake when GDGT is incorporated into liposomal systems.

In animal models, researchers observed ~9x higher oral bioavailability for vancomycin and ~11x higher oral mRNA delivery.

Intravenous formulations containing GDGT have also demonstrated stealth-like circulation behavior without PEG incorporation. This characteristic draws attention in vaccine and nucleic acid delivery research, particularly in applications seeking alternatives to PEGylated systems because of potential immunogenicity concerns.

Key features

• Ether-linked tetraether structure supports exceptional thermal, pH, and oxidative stability
• Reported PEG-free stealth behavior in intravenous liposomal systems
• Strong storage durability, including >95% integrity after six months in lyophilized archaeosome studies
• Compatible with delivery platforms for small molecules, proteins, and nucleic acids

Put your research in experienced hands with Avanti Research™, widely recognized for our lipid manufacturing expertise and longstanding role as a trusted supplier to pharmaceutical developers and leading research institutions worldwide.