GDGT A80588 Glycerol dialkyl glycerol tetraether

Distributed under license from NovoArc

Part of the Avanti x NovoArc partnership, GDGT is a native tetraether lipid designed to increase formulation robustness in liposomes and LNPs. Its ether-linked, tetraether architecture can span the membrane to create monolayer-like structures, supporting improved stability across challenging thermal, oxidative, and pH conditions versus conventional phospholipids.  

GDGT has been highlighted in case-study applications spanning oral and parenteral delivery (including small molecules and nucleic acids). Reported performance includes increased oral bioavailability and GI stability (e.g., oral vancomycin liposomes ~9× in vivo; oral mRNA bioavailability ~11× in rats), and PEG-free “stealth-like” behavior in IV liposomes comparable to PEGylated systems.  

Key features of this include: Extreme thermal/oxidative/pH stability from ether bonds and tetraether membrane architecture, having a non-PEG stealth option reported for GDGT-containing IV liposomes, strong storage/handling robustness (reported no degradation at room temperature; >95% integrity after 6 months for lyophilized archaeosomes), and being platform-ready across small molecules, proteins, and nucleic acids.