14:0 PE-DTPA (Gd) A89981 (Previously 790981) 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt)
Lipid nanoparticles containing DMPE-DTPA(Gd) provide high quality contrast enhanced vascular MRI at 97% reduced dose of Gd and do not rely on renal clearance.
Structure as shown by Cormode, D.P. et al
Cormode, D.P., T. Skajaa, M.M. van Schooneveld, R. Koole, P. Jarzyna, M.E. Lobatto, C. Calcagno, A. Barazza, R.E. Gordon, P. Zanzonico, E.A. Fisher, Z.A. Fayad, and W.J. Mulder. (2008). Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform. Nano Lett 8:3715-23. [PubMed]
Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol
