DMG-PEG2k-TCO A89023 (Previously 793023) 1,2-dimyristoyl-rac-glycero-3 -[TCO (polyethylene glycol)-2000]
One of the challenges with Lipid Nano particles (LNPs) is the ability to be able to deliver the payload to the desired cells. However, certain functional groups could target desirable cells, but how does one functionalize a LNP with a desired functional group to achieve delivery to a specific cell? Click-chemistry offers some hope for easier linking of functional groups to other molecules to synthesize larger, more complex molecular structures. TCO PEG lipids offer the ability to easily conjugate to specific biomolecules via metal free click chemistry to tetrazines. By changing the PEG length, one can change the micelle size, immunological safety, and change the drug release rate.
