14:0 PG 840445 1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)

14:0 PG or 1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol), sodium salt (DMPG) is a form of phosphoglyceride (PG), a minor component (only one to two percent) of most cell membranes. Phosphoglyceride (PG), also known as glycerophospholipid, forms an essential component of membrane bilayers, including up to 20 percent of bacterial membranes across diverse biological systems.

14:0 PG is integral to cellular membranes, with its unique structure consisting of a three-carbon glycerol backbone, two long-chain fatty acids, esterified to hydroxyl groups on carbons 1 and 2 of the glycerol, and phosphoric acid esterified to the C3 hydroxyl group of glycerol. PG is abundant in all cell membranes and is present in minimal quantities in fat reserves. It's used by cells as part of the transition to cardiolipin synthesis.

Additionally, PG can be detected at higher concentrations (up to 11 percent of the total lipid content) within lung surfactants. Its presence in amniotic fluid serves as an indicator of fetal lung maturity and forms the foundation of clinical testing for fetal fitness.

Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol