18:1 Cyanine 5 PC 850483 1,2-dioleoyl-sn-glycero-3-phosphocholine-N-(Cyanine 5)

Product Overview:

18:1 Cyanine 5 PC (Cyanine 5-Phosphatidylcholine) is a fluorescently labeled lipid that integrates the cyanine dye Cyanine 5 (a far-red fluorescent probe) with the phosphatidylcholine (PC) backbone, providing a versatile tool for molecular imaging and cellular tracking applications. Cyanine 5 is a fluorescent probe that emits near the infrared region and has good photostability. This probe allows for deep tissue penetration and minimal interference from biological autofluorescence, thus making 18:1 Cyanine 5 PC useful for in vivo imaging and real-time biological monitoring. Cyanine 5 probes are commonly used in applications such as cellular uptake studies, drug delivery tracking, and biomolecular interaction assays. Cyanine 5 PC is often conjugated with targeting ligands and therapeutic agents which enhances the precision and functionality of lipid nanocarriers in targeted therapy and diagnostic applications. Additionally, 18:1 Cyanine 5 PC has been used to track cell membrane dynamics and lipid bilayer behavior in real time.

Sources:

Mocan, T., et al. (2018). Cyanine-based fluorescent probes for molecular imaging: Synthesis and applications in biomedicine. Biomolecules, 8(4), 153.

Gupta, B., et al. (2020). Recent advancements in Cyanine 5 and Cyanine 5.5 conjugates for biomolecular imaging. Biochimica et Biophysica Acta (BBA) - General Subjects, 1864(7), 128474.

Li, H., et al. (2019). Real-time imaging of cellular interactions with Cy5-labeled liposomes for targeted drug delivery. Molecular Pharmaceutics, 16(10), 3764-3773.

Zhou, J., et al. (2020). In vivo fluorescence imaging using Cy5-labeled liposomes for cancer diagnosis and therapeutic monitoring. Journal of Nanobiotechnology, 18(1), 99.