DOPE (18:1 PE) A80725 (Previously 850725) 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
18:1 (Δ9-Cis) PE (DOPE), also known as 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, is a type of neutral phospholipid that displays sensitivity to changes in acidity (pH change). At acidic, it is an inverted hexagonal micelle and becomes spherical micelle at alkaline pH. DOPE is a neutral helper phospholipid used in gene and drug delivery liposomal formulations. When combined with cationic phospholipids, DOPE increases the transfection efficiency in a variety of cell types.