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C8 L-threo-Lactosyl(ß) Ceramide (d18:1/8:0)

C8 L-threo-Lactosyl(ß) Ceramide (d18:1/8:0) A86575 (Previously 860575) D-lactosyl-ß1-1'-N-octanoyl-L-threo-sphingosine

C8 L-threo-Lactosyl(ß) Ceramide (d18:1/8:0)

β-D-lactosyl-N-octanoyl-L-threo-sphingosine, (1) selectively inhibits caveolar endocytosis and SV40 virus infection, (2) blocks the clustering of lipids and proteins into GSLs and cholesterol-enriched microdomains (rafts) at the PM, and (3) inhibits β1-integrin activation and downstream signaling. Singh, R.D., E.L. Holicky, Z.J. Cheng, S.Y. Kim, C.L. Wheatley, D.L. Marks, R. Bittman, and R.E. Pagano. (2007). Inhibition of caveolar uptake, SV40 infection, and β1-integrin signaling by a nonnatural glycosphingolipid stereoisomer. J Cell Biol 176:895-901.

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