18:1 DBCO PE 870129 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-dibenzocyclooctyl
Product Overview:
18:1 DBCO PE is a functionalized lipid that combines the biocompatible properties of phosphatidylethanolamine (PE) with the reactive dibenzocyclooctyne (DBCO) group, enabling the use of click chemistry in various biomedical applications. By being a clickable lipid, it creates a versatile platform for creating functionalized lipid systems for drug delivery, molecular imaging, and targeted therapies. This lipid can be conjugated with targeting ligands such as fluorescent dyes or therapeutic agents offering precise targeting and controlled release of drugs. This lipid is also particularly valuable in creating nanoparticles for for cancer treatment and gene therapy.
Sources:
Liu, Y., et al. (2017). Copper-free click chemistry for functionalization of lipid nanoparticles: A new approach to target-specific drug delivery. Journal of Controlled Release, 263, 9-18.
Patra, A. R., et al. (2018). Liposomal formulations for targeted drug delivery: Advances in cancer treatment. International Journal of Nanomedicine, 13, 6399-6412.
Zhao, X., et al. (2021). Bioorthogonal functionalization of liposomes using DBCO-PE for targeted therapy and imaging applications. Biomaterials Science, 9(3), 767-778.
Santiago, L. L., et al. (2019). Engineering liposomal systems with bioorthogonal chemistry for targeted drug delivery. Bioconjugate Chemistry, 30(9), 2496-2504.
