18:1 PE (DOPE) pSar25 A87341 (Previously 870341) 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-polysarcosine-25 (ammonium salt)
Polymers are a common modification made to lipids used for liposomal and lipid nanoparticle delivery systems. Adding a polymer-conjugated lipid to a formulation can improve several properties of the drug delivery system. Polyethyleneglycol (PEG) has historically been the most common polymer used in clinical practice. But recent studies have shown polysarcosine polymer-conjugated lipids to have similar stealth properties as PEG-conjugated lipids, but with the added bonus of an improved safety profile. Use 18:1 PE (DOPE) pSar25 as an alternative to 18:1 PE (DOPE) PEG2000 in your lipid formulations research today!
The molecular weight and exact mass are averages based on the polydispersity of PEG.
Polysarcosine-liposome formulations for mRNA delivery targeting the brain
