ALC-0159 A80159 (Previously 880155) Methoxypolyethyleneglycoloxy(2000)-N,N-ditetradecylacetamide

Methoxypolyethyleneglycoloxy(2000)-N,N-ditetradecylacetamide, or ALC-0159, is a methoxypolyethylene glycol (PEG-2000) conjugated lipid and is designed to enhance the stability and biocompatibility of LNP drug delivery systems.

By forming a hydrophilic shield, ALC-0159 significantly reduces immune recognition to increase circulation time and improve bioavailability. As a key component in mRNA-based vaccines, this PEGylated lipid carries out a fundamental function in efficient nanoparticle encapsulation and intracellular delivery. This makes it indispensable in cutting-edge pharmaceutical and gene therapy applications.

Other notable applications include its ability to improve stability, bioavailability, and reduced immunogenicity in CRISPR, siRNA, and antisense oligonucleotide uses, as well as driving next-generation RNA-based therapies, which enables improved systemic circulation and controlled release.

And whether you’re in preclinical research or commercial production, Croda Pharma can provide GMP-certified lipid options to meet your needs. Explore their pharmaceutical-grade offerings for high-quality, scalable solutions.