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DSG-pSar25-Maleimide

DSG-pSar25-Maleimide A88267 (Previously 880267) 1,2-distearoyl-sn-glycero-3-succinyl-N-polysarcosine-25-N-Maleimide

DSG-pSar25-Maleimide
DSG-pSar25-Maleimide is a lipid that is composed of a DSG unit conjugated to a pSar25 polymer. Polysarcosine (pSar) lipids are offered as alternatives to traditional PEGylated lipids used in RNA delivery vehicles. Compared to similar PEGylated lipid nanoparticles (LNPs), pSar LNPs have shown improved mRNA transfection potency and improved safety profiles. This compound features a maleimide group enabling a highly versatile platform for bioconjugation. The maleimide group reacts with thiol groups on peptides, facilitating the attachment of bioactive molecules to the lipid nanoparticle surface. This unique capability allows for the creation of LNPs tailored for targeted delivery to specific cells.
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*The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada

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