Dlin-MC3-DMA 890906 (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate

Dlin-MC3-DMA is a synthetic ionizable lipid with a pKa value around 6.4 that is predominantly used in the formation of LNPs for drug delivery. Dlin-MC3-DMA has been used clinically for the delivery of small interfering RNA (siRNA) and messenger RNA (mRNA). It has also been used for the transfection of plasmid DNA (pDNA) to the spleen in mice.1

Product is provided for Research Use Only intended for seeking Food and Drug Administration’s (FDA) approval under The Hatch-Waxman Act (formally known as the Drug Price Competition and Patent Term Restoration Act of 1984).

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References:

1. Jayaraman M, Ansell SM, Mui BL, Tam YK, Chen J, Du X, Butler D, Eltepu L, Matsuda S, Narayanannair JK, Rajeev KG, Hafez IM, Akinc A, Maier MA, Tracy MA, Cullis PR, Madden TD, Manoharan M, Hope MJ. Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8529-33. doi: 10.1002/anie.201203263. Epub 2012 Jul 10. PMID: 22782619; PMCID: PMC3470698.