306Oi10 890908 tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate
306Oi10 is a synthetic branched-tail ionizable lipid with a pKa of 6.4 that is predominantly used in the formation of LNPs with mRNA that target the liver. The branched-tail results in a ten-fold luciferase expression in mice compared to its linear counterpart. This finding shows that branched-tail ionizable lipids have a profound impact on surface ionization compared to lipids with linear tails. Certain LNP formulations result in increased surface ionization and more effective mRNA delivery.1
Product is provided for Research Use Only intended for seeking Food and Drug Administration’s (FDA) approval under The Hatch-Waxman Act (formally known as the Drug Price Competition and Patent Term Restoration Act of 1984).
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References:
1. K. A. Hajj, R. L. Ball, S. B. Deluty, S. R. Singh, D. Strelkova, C. M. Knapp, K. A. Whitehead, Small 2019, 15, 1805097. https://doi.org/10.1002/smll.201805097
