The role of gangliosides in research

Gangliosides are complex glycosphingolipids consisting of a foundational ceramide portion and a glycan moiety enriched with one or more sialic acid residues. Found in the plasma membrane and cell surface of neuronal cells, these ganglioside species play a crucial role in cell-to-cell communication, membrane microdomain organization, signaling protein interactions, and broader aspects of neural differentiation and synaptic function.

Since brain gangliosides and their metabolic fate influence key biological functions, changes in ganglioside metabolism serve as key biomarkers in both healthy and disease states—from metabolic to neurodegenerative disorders.

Accurate quantification of gangliosides remains challenging due to their complexity and variable abundance, making synthetic isotope-labeled gangliosides critical internal standards for normalizing results, enhancing data quality, and ensuring consistent comparisons across samples and studies.

Advantages of Avanti Research™ isotope-labeled gangliosides and glycosphingolipid standards

High isotopic enrichment and accuracy in ganglioside metabolism studies

Each isotope-labeled ganglioside is synthesized for clear mass differentiation in LC-MS and MS/MS analyses, enabling precise quantification of ganglioside species derived from plasma membranes and cell surfaces.

These labeled gangliosides improve quantification of biological function, ganglioside metabolism, and membrane dynamics in lipidomics and neurobiology.

Exceptional purity and validation of isotope-labeled glycosphingolipids

All of our compounds undergo rigorous advanced analytical testing for isotopic enrichment, ceramide moiety composition, and sialic acid residues. Methods in these tests include purity verification and isotopic composition analysis.

Certificates of Analysis are available for all Avanti Research™ products, ensuring confidence for biological studies, neurodegenerative disorder research, and specialized ganglioside biochemistry.

Reproducible performance across lipidomics and neurobiology applications

Our ganglioside standards are the go-to, reliable choice by researchers worldwide studying brain gangliosides, neuronal cells, and signaling proteins. Consistent and traceable, they deliver high-resolution results for exploring metabolic processes, cell-to-cell communication, and plasma membrane organization in vertebrate cells and cultured cells.

Croda pharma quality system for ganglioside derivatives and lipid production

Each Avanti Research™ ganglioside derivative meets the highest standards of purity, traceability, and reproducibility, supporting research on artificial membranes, fluorescent gangliosides, and the metabolic fate of gangliosides across biological systems.

Applications of isotope-labeled gangliosides

Our high-purity labeled gangliosides provide researchers with reproducible, mechanistic insights into ganglioside species, biological function, and metabolic processes in both normal and disease animal models.

Quantitative lipidomics using labeled gangliosides: Our labeled gangliosides enable researchers to accurately profile ganglioside species and classes using LC-MS or MS/MS.

Metabolic tracing of ganglioside synthesis and degradation pathways: Researchers rely on our stable isotope-labeled gangliosides to trace ganglioside metabolism, from biosynthesis to catabolism, within neuronal cells and vertebrate tissues.

Neuroscience research: With our labeled gangliosides, neuroscience researchers can study the roles of brain gangliosides in neural development, repair, and cell-to-cell communication, examining signaling proteins, membrane domains, and lipid rafts that regulate neuronal cell differentiation and myelin stability in both animal models and human fibroblasts.

Cellular signaling: Researchers utilize our labeled gangliosides to investigate how ganglioside species influence the behavior of signaling proteins and membrane domain stability at the plasma membrane. Labeled gangliosides enable researchers to monitor real-time interactions and spatial distribution in artificial membranes or in vertebrate cells, thereby uncovering the mechanisms of lipid–protein communication.

Comparative analysis: Our isotope-labeled gangliosides help researchers enhance data consistency across biological replicates and experimental conditions. Their reproducible isotopic enrichment enables accurate comparisons of ganglioside metabolism, biochemical composition, and ganglioside concentration across various tissue types, ranging from brain samples to cultured cells.

Why choose Avanti Research™ for sourcing research-ready labeled gangliosides

As part of Croda, Avanti Research™ connects lipids, technology, and cell biology through a shared commitment to innovation and scientific excellence.

Our isotope-labeled gangliosides exemplify this mission—offering unmatched purity and reproducibility for researchers worldwide.

With our research-use materials, we empower discoveries across lipid discovery, characterization, and formulation workflows. Reach out to our team to discuss your project or request a quote.

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FAQ

What is the purpose of isotope-labeled gangliosides?

Labeled gangliosides serve as internal standards for quantitative analysis in lipidomics and neurobiology, ensuring reproducibility and data accuracy.

What labeling isotopes are available?

We offer multiple isotope configurations, including deuterium (²H), carbon-13 (¹³C), and nitrogen-15 (¹⁵N), optimized for mass spectrometry workflows.

To browse our full catalog of labeling isotopes, please scroll to the top of this page.