22:6 BMP (R,R) 791224 sn-(1-didocosahexaenoyl-2-hydroxy)-glycerol-3-phospho-sn-3'-(1'-didocosahexaenoyl-2'-hydroxy)-glycerol (ammonium salt)
22:6 BMP (R,R) is a stereochemically defined BMP containing two 22:6 DHA chains. BMP is a low-abundance but important phospholipid enriched in late endosomal membranes, mostly associated with membrane remodeling and lipid trafficking. BMP levels and/or species profiles are often altered in lysosomal storage disorders and are commonly monitored as biomarkers of drug-induced phospholipidosis1; emerging studies also support BMP’s utility in translational biomarker panels2. With the polyunsaturated 22:6 acyl chains and defined (R,R) stereochemistry, this lipid is a valuable reference standard for lipidomics method development and LC-MS/MS quantitation, as well as for probing acyl-chain and stereochemistry-dependent BMP biology.
1) Meikle PJ, Duplock S, Blacklock D, Whitfield PD, Macintosh G, Hopwood JJ, Fuller M. Effect of lysosomal storage on bis(monoacylglycero)phosphate. Biochem J. 2008 Apr 1;411(1):71-8. doi: 10.1042/BJ20071043. PMID: 18052935.
2) Ørum K, Stormoen DR, Lauritsen J, Rohde M, Jäättelä M, Pappot H. An example of drug repurposing: ebastine in combination with docetaxel as a treatment for metastatic castration-resistant prostate cancer-the EXUROC prostate study, a clinical trial protocol. BMC Urol. 2025 Jul 4;25(1):154. doi: 10.1186/s12894-025-01837-0. PMID: 40611014; PMCID: PMC12226910.
