Hydroperoxy POPC 870610 Hydroperoxy POPC

 As a primary product of lipid peroxidation, hydroperoxy phospholipids serve as critical markers of cellular oxidative stress. The introduction of the polar hydroperoxide group into the hydrophobic acyl chain alters membrane biophysics, causing the oxidized tail to bend toward the lipid-water interface. This disrupts lipid packing, increases membrane permeability, and alters lateral diffusion.  

Biologically, OxPLs like Hydroperoxy POPC act as damage-associated molecular patterns (DAMPs) and potent lipid mediators. They are recognized by receptors such as TLR4 and scavenger receptors like CD36, playing pivotal roles in triggering inflammatory signaling, macrophage foam cell formation, and apoptosis. This lipid standard is essential for researchers investigating atherosclerosis, neurodegeneration, cardiovascular diseases, and the fundamental mechanisms of oxidative membrane damage.