FP-20, sodium salt A89857 (Previously 699857) sodium (2R,3S,4R,5R,6S)-5-dodecanamido-4,6-bis(dodecanoyloxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl phosphate
FP-20 sodium salt is a synthetic adjuvant and toll-like receptor 4 (TLR4) agonist designed to improve immune responses in vaccine formulations. It features a glucosamine monosaccharide core with three C12 fatty acid chains and a phosphate group.
A 2024 Journal of Medicinal Chemistry study (ACS J. Med. Chem. 2024, 67, 8, 5678–5692) reports its phase-transition temperature (Tₘ) is 43.9 °C, highlighting its favorable thermal stability for vaccine formulation and storage.