Tauro-α-muricholic acid, sodium salt A80243 (Previously 700243) 5ß-cholanic acid-3α,6ß,7α-triol N-(2-sulphoethyl)-amide, sodium salt

Tauro-α-Muricholic Acid is a taurine-conjugated form of bile acid (BA), α-muricholic acid, and a rodent metabolite, present in low concentrations in human serum.

α-Muricholic acid is included in the class of muricholic acids in which the hydroxy groups at positions 6 and 7 have respectively β- and α-configuration.

Tauro-α-Muricholic Acid is known to be a reversible and competitive antagonist of the Farnesoid X receptor (FXR).

The Farnesoid X receptor is a part of the nuclear receptor superfamily and has been proven to play a key role in the regulation of a wide range of metabolic pathways. FXR is activated by BAs and actually modulates their synthesis, conjugation, and secretion. The receptor also participates in the control of other lipids and glucose homeostasis and metabolism.

Therefore, Tauro-α-Muricholic Acid can be included in various analyses evaluating FXR activity and potential therapeutic properties.

Tauro-α-Muricholic Acid is also widely used as an experimental detergent in cholestasis studies.

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