Tauro-ß-muricholic acid, sodium salt A80244 (Previously 700244) 5ß-cholanic acid-3α,6ß,7ß-triol N-(2-sulphoethyl)-amide, sodium salt

Tauro-β-Muricholic Acid is an endogenous steroid metabolite, released from the liver in human and rat organisms.

The compound is derived from the bile acid (BA) β-muricholic acid through an enzyme-regulated process of conjugation between the BA and the amino acid taurine. β-Muricholic acid is a member of the group of muricholic acids and its hydroxy groups at positions 6 and 7 have β-configuration.

Tauro-β-Muricholic Acid is most commonly used as an experimental metabolite in cholestasis research.

The compound, together with other taurine-conjugated forms of muricholic acids, is also believed to be a reversible and competitive antagonist of the Farnesoid X receptor (FXR).

Farnesoid X receptor belongs to the superfamily of nuclear receptors and has an important role as a molecule that contributes to the physiological occurrence of different metabolic reactions. It’s related to BA metabolism and homeostasis and is activated by BAs at the same time.

Hence, Tauro-β-Muricholic Acid can be implied as a detergent in experimental work concerning FXR properties and potential effects in the treatment of certain conditions.

The taurine conjugate is also considered to increase concentrations of serum cytokines, including IL-6, IL-17, and IFN-γ.

Rely on Avanti Research to provide you with a highly pure and stable Tauro-β-Muricholic Acid research product for quality experimental development.