14:0 PC (DMPC) A80345 (Previously 850345) 1,2-dimyristoyl-sn-glycero-3-phosphocholine
1,2-dimyristoyl-sn-glycero-3-phosphocholine, or 14:0 PC (DMPC), is a synthetic phospholipid with two 14-carbon saturated acyl chains at the sn-1 and sn-2 positions of glycerophosphocholine. The phospholipid’s phase transition temperature (around 23°C) has helped make it a staple in membrane biophysics, liposome formulations, and lipid-based drug delivery systems. Additionally, it is a preferred lipid for modeling biological membranes and understanding phase transitions in controlled environments due to its thermotropic behavior.
Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol
