n-dodecyl-ß-D-maltoside (DDM) A80520 (Previously 850520) n-dodecyl-β-D-maltopyranoside

n-dodecyl-ß-D-maltoside (DDM), or n-dodecyl-β-D-maltopyranoside, is a high-purity, non-ionic detergent extensively used to study the solubilization, stabilization, and structure of membrane proteins. Unlike harsh detergents that can denature proteins, DDM gently disrupts lipid bilayers while preserving protein functionality. This has made it an essential tool in biochemistry, structural biology, and pharmaceutical research.

With a low critical micelle concentration (CMC) of approximately 0.17 mM and a high aggregation number, DDM forms exceptionally stable micelles that enhance protein solubility and long-term stability. Its mild amphiphilic nature makes it a preferred detergent in cryo-EM, X-ray crystallography, and NMR studies—where maintaining native protein confirmation is highly important.