GT-11 A85494 (Previously 857395) N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide

GT-11 Dihydroceramide Desaturase Inhibitor

GT-11, also N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide, is the first inhibitor of dihydroceramide desaturase, an enzyme that converts dihydroceramide into the bioactive compound ceramide.

Dihydroceramides desaturase is an enzyme involved in the biosynthesis of ceramides. Ceramides are important molecules in the structure of cell membranes that contribute to various cellular processes including cell signaling and apoptosis, also referred to as programmed cell death. By inhibiting the activity of dihydroceramides desaturase, GT-11 can affect the production of ceramides, altering various cellular processes and pathways in which ceramides are involved.