CP-LC-0729 A86799 (Previously 860799) -
CP‑LC‑0729 is a next-generation ionizable lipid designed for efficient nucleic acid delivery using lipid nanoparticles (LNPs). Distributed and manufactured by Avanti Research™, this cationic lipid demonstrates superior performance in vivo expression and tolerability, particularly for hepatic and pulmonary delivery applications.
CP-LC-0729 has a measured pKa of 6.78 and promotes effective endosomal escape, an essential mechanism for successful mRNA, saRNA, or circRNA release into the cytosol. Its branched hydrophobic structure supports the formation of stable, homogenous LNPs with high encapsulation efficiency and low polydispersity. It has significantly outperformed benchmark lipids, demonstrably improving expression levels and lowering systemic toxicity (Mata, E., Broset, E., Matute, C. et al. 2025).
