18:0-PhoDAG A87621 (Previously 870621) 1-stearoyl-2-[(E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl]-sn-glycerol

Diacylglycerols (DAG) play a key role in transient receptor potential (TRP) channels. TRP channels are linked to a wide variety of biological processes including the body's ability to sense and process pain, temperature, tastes, pressure, and vision. 18:0 PhoDAG is embedded with a photoswitchable azobenzene moiety that allows rapid photoactivation of these DAG-sensitive TRP channels. The photoswitchable DAG allows for the further exploration of the physiological relevance of these TRP channels in the body’s homeostasis process.

Leinders-Zufall, T., Storch, U., Bleymehl, K.; et. al. PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels. Cell Chem. Bio. 2020 Dec 21; 2(25): 215-223. https://doi.org/10.1016/j.chem...