DSPE-PEG(2000) Carboxylic Acid A80135 (Previously 880135) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt)
The chemical name for DSPE PEG 2000 Carboxylic Acid is 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt) or DSPE-PEG-COOH. Based on the polydispersity of PEG, its molecular weight is 2780.38, and its exact mass is 2778.7.
This specialized lipid molecule has been used in various applications in the field of biotechnology, pharmaceuticals, and drug delivery. It is a derivative of phospholipids and is part of the broader family of liposomal formulations.
The DSPE's hydrophobic characteristics facilitate the encapsulation and gathering of other hydrophobic drugs. In the presence of an activator like EDC or HATU, the -COOH group can readily react with primary amines, resulting in the formation of a stable amide bond.
DSPE-PEG 2000 carboxylic acid has been utilized to attach ITGA2 antibodies to liposome surfaces, create atosiban-conjugated liposomes, and produce dual complementary liposomes.
