DSG-PEG 2000 880152 distearoyl-rac-glycerol-PEG2K

Representative Structure

The molecular weight and exact mass are averages based on the polydispersity of PEG.

Avanti Research™ DSG-PEG 2000 (distearoyl-rac-glycerol-PEG2K) is a non-ionic, PEGylated lipid that serves as a steric‐stabilizing excipient in lipid-based formulations (e.g., liposomes, lipid nanoparticles), contributing to surface stabilization and prolonged circulation by reducing non-specific interactions.

The DSG-PEG 2000 product is composed of a hydrophobic distearoyl-rac-glycerol anchor covalently linked to a hydrophilic polyethylene glycol (PEG 2000) chain, enabling the DSG moiety to embed in the lipid bilayer while the PEG segment extends outward to form a hydrated, neutral surface layer. This structure minimizes non-specific interactions, enhances colloidal stability, and supports prolonged circulation and predictable particle behavior in biological systems.

Applications

DSG-PEG 2000 is used as a surface-stabilizing excipient in research involving:

• Lipid nanoparticle (LNP) and liposome preparation for small interfering RNA (siRNA) delivery research
• Nanocarrier-based delivery of nucleic acids, peptides, or small molecules
• Formulations requiring reduced aggregation during preparation or storage (e.g., lipid dispersions, colloidal suspensions)
• Systems where a neutral, steric barrier is needed to modulate surface interactions

Because the molecule is non-ionic, it is often selected when charge neutrality and minimized protein binding are desired.

Formulation and handling

Incorporate during lipid film hydration, solvent exchange, microfluidic assembly, or post-insertion into preformed vesicles. The final PEG density should be experimentally adjusted based on the intended physical and biological characteristics of the formulation.

Store at −20°C, protected from moisture and light. Allow the vial to reach room temperature before opening to avoid condensation.

Packaging

Supplied in pre-measured, quality-controlled quantities with a batch-specific certificate of analysis. The reported molecular weight is an average value that reflects the normal polydispersity of PEG; exact mass cannot be assigned

Avanti Research™ provides DSG-PEG 2000 in 1 g and 5 g powder packaging for research use only. For sublicense discussions or larger quantities, please email our customer service representatives at customerservice@avantilipids.com.

Why researchers choose Avanti Research™

At Avanti Research™, we take pride in producing structurally defined, analytically validated lipid molecules. With its ability to minimize non-specific interactions in lipid nanoparticle and liposome preparations, DSG-PEG 2000 has become an essential component in advanced formulation research.

Supported by Croda Pharma’s global quality systems, every Avanti Research™ product is traceable, consistent, and scalable for advanced research applications.

With over 50 years of expertise, Avanti Research™ continues to help researchers accelerate discovery.