DOPE-PEG(2000) Amine 880234 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt)

DOPE-PEG(2000) Amine, or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000], is a synthetic phospholipid-polyethylene glycol (PEG) conjugate, uniquely engineered for advanced drug delivery research. This linear heterobifunctional PEGylation reagent with an unsaturated dope phospholipid and an amine (DOPE-PEG-Amine, MW 2K) is used to modify liposome surface with biomolecules consisting of amine-reactive groups.

Comprising 1,2-Dioleoyl-sn–glycero-3-phosphoethanolamine (DOPE) and a PEG molecule of approximately 2000 Daltons, this compound features an amine termination. The intricate combination of DOPE's unsaturated phospholipid and the bioconjugation-friendly amine makes it an invaluable tool in both targeted drug delivery and liposomal drug delivery systems.

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Product details

Product Type

Lipids

Product Category

Polymers & Polymerizable Lipids - Functionalized PEG Lipids

Application

In targeted drug delivery, DOPE-PEG(2000) Amine shines by modifying liposome surfaces with biomolecules bearing amine-reactive groups such as NHS and thiolate. This PEGylation reagent helps improve drug solubility within lipid bilayers, while the PEG moiety imparts stealth properties to the delivery system, extending circulation half-life and minimizing non-specific protein binding or cell adhesion. The amine group helps bioconjugate targeting molecules like antibodies, aptamers, proteins, and peptides, making it an essential component for preparing grafted or PEGylated liposomes and micelles. Additionally, it has proven efficacy in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for anticancer drug delivery and imaging applications.

Data

Hygroscopic	No
Light sensitive	No
Molecular formula	C₁₃₂H₂₆₂N₃O₅₄P (average MW due to polydispersity of PEG)
Percent composition	C 56.90%, H 9.48%, N 1.51%, O 31.00%, P 1.11%
Purity	>99%
Stability	1 Year
Storage temperature	-20°C
CAS number	2342575-85-1 CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula weight	2786.49
Exact mass	2784.76
Synonyms	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-amino(polyethylene glycol)-2000] (ammonium salt)

Certificates of Analysis

880234 - ChemDraw File
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ChemDraw File

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880234C - Safety Data Sheet
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Safety Data Sheet

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