DSPE-PEG(3400) Amine A88256 (Previously 880256) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-amino(polyethylene glycol)-3400] (ammonium salt)

DSPE-PEG(3400) Amine is a lipid that is predominantly used in LNPs for drug delivery. In targeted drug delivery, DSPE-PEG(3400) shines by modifying liposome surfaces with biomolecules bearing amine-reactive groups such as NHS and thiolate. This PEGylation reagent helps improve drug solubility within lipid bilayers, while the PEG moiety imparts stealth properties to the delivery system, extending circulation half-life and minimizing non-specific protein binding or cell adhesion. The amine group helps bioconjugate targeting molecules like antibodies, aptamers, proteins, and peptides, making it an essential component for preparing grafted or PEGylated liposomes and micelles. Additionally, it has proven efficacy in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for anticancer drug delivery and imaging applications.