DSPE-PEG2K-triGalNAc (II) 880260 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000]-N-trident (N-acetylgalactosamine), ammonium salt

Patent Pending.  Application No. 63/776,541

Overview

DSPE-PEG2K-triGalNAc (II) from Avanti Research™ is a functionalized PEG lipid that enhances targeted drug delivery by binding to the Asialoglycoprotein Receptor (ASGPR), which is predominantly found on the surface of liver cells. By functionalizing DSPE-PEG2K with triGalNac, this PEG lipid can be used in the formation of liposomes or lipid nanoparticles that target the liver for drug delivery.

The “(II)” designation denotes a distinct ligand-display topology, reflecting a structural variation in the tri-GalNAc conjugation pattern that enables controlled comparison with alternative tri-GalNAc display formats.

Application

Avanti Research™ DSPE-PEG2K-triGalNAc (II) is used to introduce structured tri-GalNAc surface display on liposomes, lipid nanoparticles, or other lipid-based carriers. It is particularly suited for research involving:

• ASGPR-associated hepatocyte interaction studies
• Evaluation of multivalent ligand clustering effects
• Optimization of surface ligand density in nanoparticle formulation
• Comparative hepatocyte binding model development studies
• Liver-directed LNP or liposome research workflows

Formulation and handling

We offer DSPE-PEG2K-triGalNAc (II) for research-use only (not for therapeutic or clinical applications) in an ammonium salt powder form, compatible with aqueous handling and solvent-assisted formulation workflows.

DSPE-PEG2K-triGalNAc (II) from Avanti Research™ is a high-purity (Purity >99%) composition (C₁₉₅H₃₇₆N₁₃O₈₄P), confirmed by analytical validation. Batch-specific COA provided.

Handling procedures are as follows

• Incorporate DSPE-PEG2K-triGalNAc (II) into formulations during lipid film hydration, solvent exchange, microfluidic assembly, or via post-insertion into pre-formed vesicles.
  
  

• Store the product at −20°C, protected from moisture and light.

• Allow the product to warm to room temperature in the package before opening to prevent condensation.

• Optimize ligand mol% based on your application’s required particle surface presentation level.

Packaging & specifications

Avanti Research™ supplies DSPE-PEG2K-triGalNAc (II) for research use only in pre-measured, quality-controlled quantities (5 mg units or in bulk upon request), accompanied by batch-specific certificates of analysis to support reproducibility and verify purity and composition. Molecular formula (C₁₉₅H₃₇₆N₁₃O₈₄P) and approximate MW reflect normal PEG polydispersity.

For discussions regarding sublicenses or larger quantities, please email our customer service representatives at customerservice@avantiresearch.com.