DSPE-PEG8 Biotin A88276 (Previously 880276) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(octaethylene glycol)] (ammonium salt)

DSPE-PEG8 is a type of functionalized PEGylated phospholipid commonly used in drug delivery systems, especially in the formulation of lipid nanoparticles. Attaching Biotin to DSPE-PEG8 creates a biotinylated lipid; this modification allows for incorporation into liposomes or LNPs, can be used in biosensors, and enables modular targeting for drug delivery. The Biotin attachment also introduces a high-affinity binding site for streptavidin or avidin, proteins that bind strongly to biotin. By enabling this kind of site-specific attachment, DSPE-PEG8 Biotin helps researchers create more targeted delivery systems—improving cellular uptake and therapeutic precision. It’s a great option for anyone working on LNP formulations for mRNA delivery, gene editing, vaccines, or other applications where targeting really matters.