Inhibitors of Sphingolipid Metabolism

A85392 (857392) (R)-FTY720-OMe

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A85393 (857393) THI

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A85494 (857395) GT-11

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A86455 (860455) N-C12-deoxysphingosine

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A86456 (860456) N-C16-deoxysphingosine

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A86461 (860461) N-C12-desoxymethylsphinganine

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A86466 (860466) N-C12-desoxymethylsphingosine

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A86462 (860462) N-C16-deoxysphinganine

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A86463 (860463) N-C16-desoxymethylsphinganine

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A86467 (860467) N-C16-desoxymethylsphingosine

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A86464 (860464) N-C24:1-deoxysphinganine

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A86457 (860457) N-C24:1-deoxysphingosine

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A86465 (860465) N-C24:1-desoxymethylsphinganine

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A86468 (860468) N-C24:1-desoxymethylsphingosine

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A86493 (860493) 1-deoxysphinganine

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A86470 (860470) 1-deoxysphingosine

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A86473 (860473) 1-desoxymethylsphinganine

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A86477 (860477) 1-desoxymethylsphingosine

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A86479 (860479) Adamantanyl Galactosyl(ß) Ceramide

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A86480 (860480) C10 bisphosphonate

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A86488 (860488) Safingol

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A86771 (860771) Enigmol(2S,3S,5S)

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A86772 (860772) N-C6-Enigmol(2S,3S,5S)

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A86792 (860792) C23 Galactosyl(ß) Ceramide (d18:1/23:0)

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Sphingolipids are able to exert cell signaling effects. Ceramide is a central component of sphingolipid metabolism that is tightly regulated due to its pro-apoptotic effect. Enzymes involved in the conversion of ceramide to other sphingolipids have been targeted in drug resistance by depleting ceramide to produce pro-survival sphingolipids. Sphingosine kinases, ceramidase, glucosylceramide synthase, and ceramide synthase are all enzymes involved in the metabolism of sphingolipids. Check out Avanti’s wide variety of sphingolipid metabolism inhibitors below!

Lewis, A.C., Wallington-Beddoe, C.T., Powell, J.A., et al. Targeting sphingolipid metabolism as an approach for combination therapies in hematological malignancies. Cell Death Discov. 4, 72 (2018). https://doi.org/10.1038/s41420-018-0075-0

Name	Typical content	Expires
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Name	Typical content	Expires
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li_gc	Used by LinkedIn to store consent of guests regarding the use of cookies for non-essential purposes.	6 months
lidc	Used by LinkedIn for routing.	24 hours
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Name	Typical content	Expires
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__Secure_YEC	Used to detect spam, fraud, and abuse to protect advertisers and YouTube creators	13 months

Name	Typical content	Expires
ANONCHK	Used by Microsoft Clarity and Microsoft Ads to store session ID for a users session to ensure that clicks are verified for reporting purposes and for personalisation.	10 mins
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MR	Used by Microsoft to support ad delivery and performance tracking.	7 days
CLID	Used by Microsoft Clarity to identify the first time a user visited any site using Clarity. Helps track user behaviour and engagement across sessions for analytics purposes.	1 year
AEC	Used by Google to ensure that requests during a browsing session are genuinely made by the user, helping to prevent malicious activity such as cross-site request forgery.	6 months
NID	Set by Google to store user preferences and personalise content, including ads on Google services. Also supports services like reCAPTCHA and SafeSearch settings.	6 months
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bcookie	LinkedIn sets this cookie from LinkedIn share buttons and ad tags to recognise browser IDs.	1 year

Inhibitors of Sphingolipid Metabolism

Acyl Carnitine Lipids

Inhibitors | Bioactive Lipids

Bioactive Ceramides