Inhibitors of Sphingolipid Metabolism

857392 (R)-FTY720-OMe

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857393 THI

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857395 GT-11

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860455 N-C12-deoxysphingosine

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860456 N-C16-deoxysphingosine

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860461 N-C12-desoxymethylsphinganine

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860466 N-C12-desoxymethylsphingosine

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860462 N-C16-deoxysphinganine

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860463 N-C16-desoxymethylsphinganine

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860467 N-C16-desoxymethylsphingosine

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860464 N-C24:1-deoxysphinganine

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860457 N-C24:1-deoxysphingosine

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860465 N-C24:1-desoxymethylsphinganine

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860468 N-C24:1-desoxymethylsphingosine

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860493 1-deoxysphinganine

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860470 1-deoxysphingosine

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860473 1-desoxymethylsphinganine

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860477 1-desoxymethylsphingosine

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860479 Adamantanyl Galactosyl(ß) Ceramide

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860480 C10 bisphosphonate

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860488 Safingol

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860771 Enigmol(2S,3S,5S)

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860772 N-C6-Enigmol(2S,3S,5S)

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860792 C23 Galactosyl(ß) Ceramide (d18:1/23:0)

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Sphingolipids are able to exert cell signaling effects. Ceramide is a central component of sphingolipid metabolism that is tightly regulated due to its pro-apoptotic effect. Enzymes involved in the conversion of ceramide to other sphingolipids have been targeted in drug resistance by depleting ceramide to produce pro-survival sphingolipids. Sphingosine kinases, ceramidase, glucosylceramide synthase, and ceramide synthase are all enzymes involved in the metabolism of sphingolipids. Check out Avanti’s wide variety of sphingolipid metabolism inhibitors below!

Lewis, A.C., Wallington-Beddoe, C.T., Powell, J.A., et al. Targeting sphingolipid metabolism as an approach for combination therapies in hematological malignancies. Cell Death Discov. 4, 72 (2018). https://doi.org/10.1038/s41420-018-0075-0

Name	Typical content	Expires
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Name	Typical content	Expires
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lidc	Used by LinkedIn for routing.	24 hours
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_bioz_depot_session	Bioz.com	Session

Name	Typical content	Expires
_gat	Used by Google Analytics to throttle request rate.	10 minutes
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_clsk	Used by Microsoft Clarity to connect multiple page views by a user into a single Clarity session recording.	1 day
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Name	Typical content	Expires
ANONCHK	Used by Microsoft Clarity and Microsoft Ads to store session ID for a users session to ensure that clicks are verified for reporting purposes and for personalisation.	10 mins
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MR	Used by Microsoft to support ad delivery and performance tracking.	7 days
CLID	Used by Microsoft Clarity to identify the first time a user visited any site using Clarity. Helps track user behaviour and engagement across sessions for analytics purposes.	1 year
AEC	Used by Google to ensure that requests during a browsing session are genuinely made by the user, helping to prevent malicious activity such as cross-site request forgery.	6 months
NID	Set by Google to store user preferences and personalise content, including ads on Google services. Also supports services like reCAPTCHA and SafeSearch settings.	6 months
IDE	Set by Google (DoubleClick), this cookie helps show relevant ads to users and measure the success of advertising campaigns.	13 months
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bcookie	LinkedIn sets this cookie from LinkedIn share buttons and ad tags to recognise browser IDs.	1 year

Inhibitors of Sphingolipid Metabolism

Acyl Carnitine Lipids

Inhibitors | Bioactive Lipids

Bioactive Ceramides