18:1 (Δ9-Cis) PC (DOPC) A80375 (Previously 850375) 1,2-dioleoyl-sn-glycero-3-phosphocholine

1,2-dioleoyl-sn-glycero-3-phosphocholine, or 18:1 (Δ9-Cis) PC (DOPC), is a highly unsaturated phospholipid that features 18-carbon acyl chains with a cis-double bond at the ninth position. This phospholipid has a low phase transition temperature of around –17°C, enabling it to remain in a fluid, liquid crystalline state at physiological temperatures. This feature makes it an essential lipid in liposomal drug delivery, cell membrane research, and biophysical studies.

Our commitment to exceptional purity and batch-to-batch consistency ensures you can trust Avanti for high-quality phospholipids in your most demanding scientific applications.

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Product details

Product Type

Lipids

Product Category

Phospholipids - PC & LPC - Unsaturated Fatty Acid

Application

Widely utilized in drug delivery systems, DOPC ensures optimal membrane fluidity, stability, and bioavailability in liposomal and lipid nanoparticle platforms. Research has shown it to be a major component of biological membrane models; it supports membrane dynamics and protein-lipid interaction studies. Additionally, 18:1 (Δ9-Cis) PC (DOPC) is pivotal in LNP-based delivery technologies as a key phospholipid in siRNA, mRNA, and DNA vaccine formulations. Because of its unique lipid crystalline properties, it is also a widely used option for phase behavior research, lipid raft studies, and vesicle fusion experiments.

Data

Hygroscopic	Yes
Light sensitive	No
Molecular formula	C₄₄H₈₄NO₈P
Percent composition	C 67.23%, H 10.77%, N 1.78%, O 16.28%, P 3.94%
Purity	>99%
Stability	1 Year
Storage temperature	-20°C
CAS number	4235-95-4 CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula weight	786.113
Exact mass	785.593
Synonyms	1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine DOPC PC(18:1(9Z)/18:1(9Z)) 730375
Transition temperature	-17°C
Solubility in different solvents	Soluble in ethanol at 5mg/mL, soluble in DMSO at 5mg/mL, soluble in Chloroform:Methanol:Water (65:25:4) at 5mg/mL

Certificates of Analysis

850375 - ChemDraw File
English: 5.0 KB

ChemDraw File

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850375C - Safety Data Sheet
English: 298.0 KB

Safety Data Sheet

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850375P - Safety Data Sheet
English: 275.0 KB

Safety Data Sheet

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