Bile Acids

High-purity bile acids for metabolic, liver, and drug research.

At Avanti Research™, we specialize in high-purity bile acid compounds crafted for precision in pharmaceutical, biochemical, and physiological studies. These essential molecules are key players in lipid digestion, cholesterol balance, and intracellular signaling, especially through nuclear receptors like FXR and TGR5. Whether you're investigating disease pathways or developing therapeutic formulations, our bile acids are available in standard research quantities and backed by complete documentation to ensure confidence in every experiment.

Scientific importance of bile acids in research and medicine.

While bile acids are commonly known for aiding digestion, their scientific value goes much deeper. These compounds act as critical metabolic homeostasis regulators and help to maintain balance in liver function, gut physiology, and systemic metabolism. Bile acids influence cholesterol turnover, lipid absorption, glucose control, and even hormone signaling through their interaction with bile salt transporters and nuclear receptors.

Research continues to demonstrate the therapeutic potential of bile acid signaling. Research by Qi et al. (2015) showed how these pathways can impact lipid regulation and glucose metabolism in urine models. Similarly, a comprehensive review by Staels and Fonseca (2009) emphasized how bile acids modulate insulin sensitivity and lipid profiles, pointing to their potential to treat metabolic disorders.

Other noteworthy studies include:

• Wahlström A et al., "Intestinal Crosstalk Between Bile Acids and Microbiota"
• Li T, Chiang JY, "Bile acid signaling in metabolic disease"

Types of bile acids available from Avanti Research™.

Avanti Research offers a wide array of purified bile acids. We select each for its unique functional role in metabolic and physiological research. Our primary bile acids, including cholic acid (CA) and chenodeoxycholic acid (CDCA), are synthesized in the liver and play a pivotal role in emulsifying dietary fats. Researchers studying gut-liver axis dynamics often turn to our secondary bile acids, such as deoxycholic acid (DCA) and lithocholic acid (LCA), which are formed by microbial metabolism in the gut and are central to microbiome interaction studies.

For investigations into bile acid transport and solubility, our conjugated bile acids, like glycocholic acid (GCA) and taurocholic acid (TCA), are commonly used in transporter and membrane permeability assays. We also supply oxidized and sulfated derivatives designed to support studies on hepatotoxicity, bile acid homeostasis, and nuclear receptor activation.

Every compound in our catalog undergoes rigorous quality control and is supplied with a Certificate of Analysis (CoA) and a Material Safety Data Sheet (MSDS) for transparency and reproducibility.

Research and development applications.

Our bile acids' versatility makes them indispensable for a wide range of research. Scientists use these compounds to model bile acid transport in liver and intestinal cells, particularly within hepatocytes and enterocytes. Our products are also used to study drug-induced liver injury (DILI) and to replicate cholestatic disease conditions in preclinical environments.

Pharmaceutical developers utilize our conjugated bile acids in oral drug formulations due to their ability to act as natural solubilizers and absorption enhancers. In cell culture and in vivo experiments, researchers rely on our bile acids to probe FXR and TGR5 activation and advance drug discovery in metabolic and inflammatory diseases. Additionally, ongoing studies are exploring how bile acids modulate the gut microbiome and influence everything from energy balance to immune signaling.

Trusted quality and documentation.

Every product we formulate and ship is defined by consistency, purity, and transparency. Most of our bile acid compounds meet or exceed 98 percent purity, as validated through our robust analytical testing. Each product comes with a full CoA and MSDS, and our rigorous quality control ensures reliable batch-to-batch performance. We also offer flexible quantities and bulk manufacturing to support long-term or high-volume research programs.

Join the community of academic institutions, biotech firms, and pharmaceutical companies across the globe that trust Avanti Research™ for their bile acid research needs.

Explore our bile acid compounds.

Dive into our full selection of bile acid compounds to find exactly what your research needs. Whether you're looking into lipid metabolism, gut-liver signaling, bile acid transporters, or pharmacological receptor studies, our collection includes:

• Primary bile acids for lipid absorption and metabolic regulation studies
• Secondary bile acids for microbiota-liver interaction research
• Glycine- and taurine-conjugated bile acids for permeability and transporter assays
• Specialty derivatives for toxicology and receptor activation models

Each product includes detailed specifications and is ready for immediate integration into your lipid research workflows. For custom synthesis requests, bulk orders, or formulation guidance, please contact our scientific support team.

Explore our Bile Acids Offering Brochure HERE