Functionalized PEG/Polymer Lipids

Overview

Functionalized PEGs and Polymer Lipids provide the critical link from stable LNPs, to targeted, multifunctional delivery systems. These materials are conjugated to highly specific, reactive headgroups, and are designed for seamless bioconjugation, click chemistry, and advanced targeting applications. 

Our broad Functionalized PEG and Polymer Lipids category includes chemical moieties such as maleimide, DBCO, TCO, triGalNAc, amine, azide, carboxylic acid, folate, carboxy NHS, biotin, and related functional motifs designed for researchers developing targeted, labeled, or surface-modified lipid systems. 

Designed for Efficient Surface Modification

Functionalized lipid systems are useful when a formulation needs more than stealth or spacer functionality alone. By pairing a lipid anchor with a PEG or Polymer chain and a reactive terminal group, these materials can enable post-insertion strategies, surface decoration, and ligand attachment for liposomes, LNPs, and other membrane-based systems. Existing Avanti products in this space span azides, DBCOs, maleimides, TCOs, carboxylic acids, NHS esters, biotin, and triGalNAc-containing PEG lipids. 

Support Click-Chemistry, Bioconjugation, and Targeted Delivery

Toolbox for Click-Chemistry and Bioconjugation

We offer a wide range of functionalized lipids for click chemistry workflows and covalent conjugation strategies. 

• Click ready azide, DBCO, and TCO lipids support copper free and strain promoted cycloaddition reactions ideal for modifying preformed nanoparticles. 
• Thiol reactive maleimide derivatives enable efficient conjugation of peptides, antibodies, proteins, or other thiol bearing probes.
• Amine reactive NHS esters and carboxylic acids allow direct linkage to amine containing ligands. 
• Primary amine PEG lipids further expand customization options, offering researchers a versatile and modular toolbox for highly controlled surface engineering.

Built In Biological Targeting

In addition to reactive chemistries, our portfolio includes functionalized lipids with built in biological targeting capabilities. 

• TriGalNAc PEG lipids support ASGPR mediated hepatocyte targeting.
• Tri mannose constructs enable lectin pathway or dendritic cell engagement.
• Folate PEG lipids facilitate uptake by folate receptor–positive cells.

Imaging, Tracking, or Affinity-based Applications

For imaging, tracking, or affinity based applications, we also offer biotinylated PEG lipids, DOTA chelating constructs, HALO tag–reactive PEG lipids, and benzylguanine PEG lipids for SNAP tag systems. 

Comprehensive Functional Groups for Broad Applications

Because our functional groups are offered across different PEG and polymer–lipid backbones, researchers can tailor their choice of anchor, spacer, and terminal chemistry to suit their application. This flexibility helps optimize insertion behavior, functional group exposure, and compatibility with formulations containing phospholipids, sterols, or cationic lipids.

Ensure compliance with our fully documented lipids.

All Avanti Research lipids and polymers are rigorously tested to fulfill the highest standards of reproducibility and regulatory compliance. Every compound is delivered with detailed documentation to support regulatory submission or publication and is backed by:

• Certificate of Analysis (CoA)
• Material Safety Data Sheet (MSDS)
• Batch traceability
• Technical support for formulation consultation

In addition, the Avanti Research Quality Management System is NSF-ISR-certified. 

Explore our lipids

For formulation guidance or custom synthesis requests, contact our scientific team for expert support.